THE EFFICACY OF LOCAL THERAPY BY DOLOBENE GEL IN COMPLEX GONARTRITIS TREATMENT

Kuryata O.V.¹, Frolova E.A. ²

• ¹Державний заклад «Дніпропетровська медична академія МОЗ України»
• ²ДЗ «Дніпропетровська медична академія МОЗ України»

Summary.  The aim of the study — to determine the efficacy of application of combined medication Dolobene gel (Pharmaceutical company ratiopharm) for complex gonartritis' treatment. There were included in the open-label clinical study 16 patients both genders (m. — 5, f. — 11) aged 46-68 yrs (av. age 57 years), suffered from osteoarthritis of knee joints, as for diagnostic criteria of ACR(ЦветковаЕ.С., 2001), withX-Raystageby Kellgren & Lawrence with damage of joint's function st. In all pts there were registered significant pain syndrome — the intensity of rest pain >30 mm, walking pain 40 mm and more by visual analogue scale (VAS). The duration of disease was 4-8 yrs (av. 5.8± 1.9). All basic group pts received medicamentous therapy by systemic NSAIDs. For intensification of anti-inflammatory effect, as well as analgetic action, there were used local applications of medication Dolobene gel, that was applied on the skin near the region of knee 3-4 times daily. The control group consisted of