DEOXYRIBONUCLEASE ACTIVITY OF IMMUNOGLOBULINS AND SERA IN SPONDYLOARTHROPATHIES
Summary. The aim of the study is to assess the immunopathogenetic role, clinical and diagnostic significance of catalytic deoxyribonuclease (DNAse) activity of polyclonal immunoglobulins (IgG) and sera in patients with spondyloarthropathies. The 266 patients with spondyloarthropathies (9S -with psoriatic arthritis, 120 - with reactive arthritis and S1 - with ankylosing spondylitis) and 69 healthy donors were examined. The method for DNAse activity assessment relied upon rivanol capacity to form a clot with DNA reversely proportional to this acid depolymerisation on the action of DNAse. The levels of DNAse activity of polyclonal IgG and sera were significantly higher in patients with spondyloarthropathies in comparison with healthy controls. The correlation between DNAse activity of polyclonal IgG and sera with some clinical, laboratory findings and treatment were revealed. The detection of high DNAse activity of polyclonal IgG and sera in patients with spondyloarthropathies indicates the role of this activity in their immunopathogenesis. The patients with psoriatic arthritis demonstrate the highest level of polyclonal IgG and serum DNAse activity. The determination of increased levels of serum and IgG DNAse activity might be applied for discrimination of psoriatic arthritis from other spondyloarthropathies.
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