SYSTEMIC LUPUS ERYTHEMATOSUS: PATHOGENETIC CHARACTERISTIC OF CLINICAL MANIFESTATIONS, CURRENT DIAGNOSTIC AND THERAPEUTIC STRATEGY Part 1

Kovalenko V.M.¹, Shuba N.M. ², Bortkevych O.P. ³, Biliavska Iu.V. ⁴

• ¹ГУ «ННЦ «Институт кардиологии им. Н.Д. Стражеско» НАМН Украины», Киев
• ²National Medical Academy of Postgraduate Education named after P.L. Shupik, Kyiv
• ³SI «NSC «Institute of Cardiology M.D. Strazhesko» NAMS of Ukraine», Kyiv
• ⁴ГУ «ННЦ «Институт кардиологии им. Н.Д. Стражеско» НАМН Украины», Киев

Summary. The analysis of latest literature data, devoted to the problem of systemic lupus erythematosus (SLE) is presented in the article. The levels of SLE incidence and prevalence, taking in account some population characteristics are described according to results of large epidemiologic studies. The recent hypothesis of SLE etiology is described, and main links of SLE pathogenesis are presented due to data of current investigations. The clinical symptoms of SLE are described according with pathogenic mechanisms of their development and presented in recent classifications. The main aim of this article is to optimize the diagnostic process and to improve the management of such patients, according to international recommendations and guidance.