ECHOGRAPHIC SIGNS OF MIOCARDIAL GEOMETRY DISTURBANCES AND EXPRESSION OF SOME HUMORAL IMMUNE FACTORS IN PATIENTS WITH RHEUMATOID ARTHRITIS

Petrov A.V., Alekseeva H.A.

• Государственное учреждение «Крымский государственный медицинский университет им. С.И. Георгиевского»

Summary. The peculiarities of changes of echo-graphic indices of left ventricular myocardium structure and function and heart rhythm in Rheumatoid Arthritis (RA) were revealed as a result of 12-month observation under 129 patients with RA and 32 practically healthy persons of control group. The connection between development of excentric left ventricular hypertrophy typical for RA and increase of cryoglobulines concentration and levels of antibodies to cardiolipin and heart chock protein associated with bacterial endotox-in in blood has been determined and the possibility to decrease production of these immune factors by adduction of hydrohycloroqine in daily dose of 400 mg in treatment complex of patients with RA has been demonstrated.