RENAL AMYLOIDOSIS IN ARTHRITIS

Bevzenko T.B.¹, Gonchar G.A.², Syniachenko O.V.³

• ¹Научно-практический центр профилактической и клинической медицины, Киев
• ²Донецкий национальный медицинский университет им. Максима Горького
• ³Донецкий национальный медицинский университет, Лиман

Summary. Among the inflammatory disease of joints the most frequent cause of secondary (reactive) renal amyloidosis is ankylosing spondyloarthritis, resulting in the increase of occurrence rates of pathological process according to the prolongation of disease duration. The risk factors of renal amyloidosis include the following: in rheumatoid arthritis — elderly age of patients, defeat of shoulder joints, endocardium and the cardiac valves, the digital arteritis and constant thrombocytosis; in Bekhterev’s disease — defeat of the sternoclavicular joints, large osteocystosis and constant hyperlipidemia; in psoriatic arthropathy — disease duration more than 15 years, exudative form of psoriasis, debut of disease from a joint syndrome and presence of persistent tendovaginitis; in gout — age of the disease beginning under 50 years, the beginning of joint syndrome from the knees, early appearance of tophus, presence of epiphysial osteoporosis, characteristic crystals in joint fluid and metabolic syndrome. Renal amyloidosis determines severity of bone-destructive changes of joints, development of extra-articular (system) signs, intensity of erosion joint bones.