HISTOPATHOLOGY OF HIP AND KNEE JOINTS TISSUES, HISTOMORPHOMETRIC INDICES AND SOME CORRELATION DEPENDENCES OF THE HEADAND DISTAL FEMUR EPIPHYSIS SPONGIOSA IN PATIENTS WITH RHEUMATOID ARTHRITIS
Grigorovsky V.V. , Gerasimenko A.S.
Summary. The purpose of the research was to study pathohistologic changes in joint tissues and histomorphometric characteristics of spongiosa in the fragments of the femur forming hip and knee joints at patients with rheumatoid arthritis (RA), who has been undergone total joint replacement and besides to establish differences between their average parameteres and correlation dependences. As a research material was represented by bone fragments that were resected from proximal and distal bone epiphyses of femur in 55 patients with RA. Histomorphometry of articular ends spongiosa (HMS) included definition of bone volume (BV/TV, %), osteoid surfaces (OS/BS, %); number of multinuclear osteoclasts in unit area (N.Oc/T.Ar, 1/sq. mm). It has been found that in tissues of hip and knee joints of patients with RA various pathologic changes have been observed which correspond to a picture of a chronic inflammation with an immune component, that are accompanied with destructive and proliferative phenomena. Comparison of average HMS-parametres has shown that all average values as: «bone volume», «osteoid surface» and «number of multinuclear osteoclasts» in femur head spongiosa are significantly higher, than in distal femoral epiphysis. In accordance with the results of correlation analysis of relations between some HMS-indices of a spongiosa state in femoral head and distal epiphysis of femur it has been found that in a femoral head HMS-indices have revealed find out higher parameters of correlation, than in distal epiphysis. The highest parameters of correlation coefficient — both for the head, and for the distal epiphysis, shows the pair «osteoid surface» — «number of osteoclasts», and the lowest parameters have been observed for the pair «bone volume» — «number of osteoclasts».
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