Сomparative features of adverse reactions caused by diclofenac and nimesulide as nonsteroidal anti-inflammatory drugs — problem of clinical pharmacology in rheumatology
Protsenko G.O. 1, Kashuba O.V. 2
Summary. The aim of the work is the information analysis of native data about adverse drug reactions (ADR) caused by diclofenac and nimesulide as nonsteroidal anti-inflammatory drugs (NSAIDs). The subject of the work is the cards-messages about diclofenac and nimesulide ADR in 1996–2010 were sent by Ukrainian physicians. Methods of the work are statistical, systems approach, semantic. Object of the work is 798 ADR reports due to medical application of diclofenac and 316 ADR reports due to medical application of nimesulide for treatment of patients with osteoarthrosis and rheumatoidal arthritis. Conclusions. The analysis of the diclofenac and nimesulide ADR data testifies to a high level of allergic reactions occurrence due to medical application of these drugs in Ukraine. Clinical features of diclofenac and nimesulide ADR and statistical significant difference between these drugs testify about necessity of diclofenac and nimesulide medical application monitoring.
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