THE ROLE OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN DEVELOPMENT OF INFLAMMATION AND IMMUNOLOGICAL REACT IN PATIENTS WITH EARLY RHEUMATOID ARTHRITIES

Gavrilenko T.I.¹, Illyash M.G. ², Mitchenko O.I. ³, Voronkov L.G. ⁴, Yakyshko L.V. ⁴, Panchenko L.M. ⁵, Rizhkova N.O. ⁶

• ¹HHЦ «Институт кардиологии им. HM. Стражеско» HAMH Украины
• ²Институт кардиологии, Киев
• ³Державна установа «ННЦ «Інститут кардіології ім. М.Д. Стражеска» НАМН України»
• ⁴ДУ «Національний науковий центр «Інститут кардіології ім. М.Д. Стражеска» НАМН України», Київ
• ⁵Державна установа «Інститут травматології та ортопедії» НАМН України», Київ
• ⁶Державна установа «ННЦ «Інститут кардіології ім. акад. М.Д. Стражеска НАМН України», Київ

Summary. Summary. Examination of 28 patients with early rheumatoid arthritis (ERA) and 15 healthy individuals. Levels of interleukines (IL)-1β, IL-17, vascular endothelial growth factor (VEGF), anti-cyclic citrullinated peptide antibodies (anti-CCP), antibodies to modified citrullized vimentin (anti-MCV), immunoglobulin (Ig)E in serum and synovial fluid were determined by enzyme immunoassay. The levels of circulate immune complexes (CIC), autoantibody (AAB) to antigen «synovia» were studied. The type of immunopathological reactions dependent on the levels of VEGF. It was found that in patients with normal VEGF level prevail autoimmune reactions (a high the serum levels anti-CCP, anti-MCV, AAB to antigen «synovia», CIC), and in patients with elevated of VEGF — immunoinflammation resctions (increase contents of IL-1β, IL-17, IgE). The differences in the contents of VEGF dependently from presence of synovitis was defined. In patients ERA with synovitis were found out higher contents of VEGF in serum; in patients without synovitis — in synovial fluid.