OLIGOARTICULARAND POLYARTICULAR VARIANTS OF JUVENILE IDIOPATHIC ARTHRITIS: STUDY OF THE PATHOGENESI

Boyko Y.Y. ¹, Chernyshov V.P.²

• ¹Львівський державний медичний університет
• ²Державна установа «Інститут педіатрії, акушерства і гінекології НАМН України», Київ

Summary. Summary. The aim of the current work was to study pathogenesis of oligoarticular and polyarticular variants of idiopathic arthritis (JIA) through determination of cytokine levels, their receptors and agonists in patients’ blood serum. The results of our investigations revealed increased IFN-γ and IL-17 levels with simultaneous decrease in of IL-10 level in blood serum of patients with polyarticular variant of JIA. Oligoarticular variant of JIA presented with increased blood TNF-α concentration together with substantial decrease of anti-inflammatory cytokine IL-10 level. Revealed changes in patients’ immune system demonstrate dis-balance between Th-1/Th-17 and Treg cells.