SIMILARITIES AND DIFFERENCES BETWEEN THE CHANGES OF THE ADSORPTION AND RHEOLOGICAL PROPERTIES OF BLOOD IN PRIMARY SYSTEMIC VASCULITIDES

Syniachenko O.V.¹, Gerasimenko A.M. ², Sinyachenko P.O.², Naumovich M.A.²

• ¹Донецкий национальный медицинский университет, Лиман
• ²Донецкий национальный медицинский университет им. Максима Горького

Summary. Summary. Goal and objectives of the work have been the comparative evaluation of clinical and pathogenetic significance of changes of adsorption and rheological properties of blood serum (ARBS) in patients with hemorrhagic vasculitis (HV), essential cryoglobulinemic vasculitis (CV) and microscopic polyangiitis (MPA), the identification of relations to the parameters of vascular endothelial function. Material and methods. 116 patients (53 with HV, 34 with CV, 29 with MPA) have been surveyed. Computer-based tensiometers MPT2-Lauda, ADSA-Toronto and PAT2-Sinterface have been used to study blood serum surface viscosity (SV), elasticity (SE), tension (ST), viscoelasticity modulus (VE), relaxation time (RT) and to calculate the inclination angle (IA) and the phase angle (PA) of tensiograms; viscometer Low-Shear-30 has been used to investigate the bulk viscosity (BV) of blood. Results and discussion. HV, CV and MPA show the increase of BV and ST of blood serum against the VE decreased and RT unchanged. There are certain differences among ARBS disorders in patients with some nosological forms of systemic vasculitis, which show no changes of IA of tensiograms in HV, SV in CV or PA in MPA, BF effecting the severity of articular syndrome in HV, SV in CV and SE in MPA, dependence of the skin lesions intensity in cases of HV on the condition of serum interfacial activity, nervous system in patients with CV on bulk viscose properties of blood, kidneys in MPA on surface viscose ones. Strong interrelationships between changes in ARBS and vascular endothelial function are observed. Conclusions. There are similarities and differences between ARSK in HV, CV and MPA that are related to the vascular endothelial dysfunction and participate in the pathogenetic construction of diseases.