PECULIARITIES OF GENERALIZED PERIODONTITIS COURSE IN RHEUMATOID ARTHRITIS
Summary. Summary. 115 patients with RA whom the level of generalized periodontitis (GP) and articular status findings have been determined; levels of C-reactive protein (CRP) and rheumatoid factor (RF) by latex agglutination method, titer of anti-CCP by ELISA method were examined. the relationship between gender, age, disease duration was аnalyzed. The highest age was ascertained in patients with III degree of GP, and the youngest are demonstrated healthy periodontal and the I degree GP. The bulk of the postmenopausal women had GP of the III degree with significant difference p=0.0286. Among the patients with minimal activity of RA there was no one examined with the III degree GP, among the patients with the II degree of RA activity part of them with GP of different degree was distributed with slight differences, although due to the quantitative percentage value the patients with the II degree GP were prevalent. The largest number of the patients, who were in the group of maximum RA activity, was presented by GP of the III degree. CRP level was significantly higher in the patients with the II and III degree GP, and in case of II degree it was in 1.9 times (р0–ІІ=0.0001), and in case of III degree (р0–ІІІ=0.0001) in 2.06 times higher than the normal range. Conclusions. In case of anti-CCP positivity the number of patients with the III degree is significantly higher than with the I (рІ–ІІІ=0.0116) and ІІ (рІІ–ІІІ=0.0021). The detection rate for the GP in case of RA increases in women, especially in postmenopause and with age of patients regardless of gender. Levels of CRP, anti-CCP and RF correlated with the degree of GP and are significantly increased in patients with severe periodontitis course. Patients with seropositive RA have a significantly higher risk of GP formation and in 2.5 times more suffer from GP compare to patients with seronegative RA.
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