INFLUENCE OF VASCULAR ENDOTHELIAL GROWTH FACTOR ON THE CLINICAL-LABORATORY-INSTRUMENTAL PARAMETRS IN PATIENTS WITH RHEUMATOID ARTHRITIS

Voronkov L.G. ¹, Komarova E.B. ²

• ¹ДУ «Національний науковий центр «Інститут кардіології ім. М.Д. Стражеска» НАМН України», Київ
• ²ГУ «Луганский государственный медицинский университет»

Summary. Summary. Patients with rheumatoid arthritis had VEGF concentration in the blood 2 times higher than the control. The high level of VEGF in the blood was associated with worsening the duration of morning stiffness, number of swollen joints, VAS and degree of functional failure of the joints. Correlation relations were detected between high levels of VEGF in blood and indicators ESR, CRP, anti-CCP, TNF-α and DAS28. The increase VEGF levels in patients with rheumatoid arthritis affects the amount of effusion in the joint cavity and the intensity of the vascularization of the synovium by ultrasound of the joints.