The frequency of allelic variants of CYP 2C9 gene in patients with rheumatic heart valves

Maliarchuk I.V.¹, Gorovenko N.G.²

• ¹Національна медична академія післядипломної освіти ім. П.Л.Шупика
• ²ГУ «Институт генетической и регенеративной медицины НАМН Украины», Киев

Summary. Summary. The aim of this study was to investigate the impact of CYP 2C9 polymorphism on formation of rheumatic and non-rheumatic heart valvular disease. Materials and methods. The study included 133 patients with heart valve replacement (67.67% male, 32.33% women, average age 51±1.2 years). 30 patients had rheumatic heart valvular dise­ase genesis and 103 patients had non-rheumatic heart valvular disease genesis. For determination of allelic variant *2 and *3 of CYP 2C9 gene the method of allele-specific PCR has been used. Results. Frequencies of the homozygous genotype CYP 2C9*1*1 (a «wild» type) was statistically higher in patients control group, compared to patients subgroup A, which may indicate a decrease the risk of rheumatic disease with damage of the heart valves in 3 times. Frequencies of the heterozygous genotype CYP 2C9*1*2 was statistically higher in patients subgroup A, which increases the risk of formation of rheumatic heart valves, more than 3 times. Conclusions. Genetic testing CYP 2C9*2 gene allows to identify patients at increased risk of developing rheumatic disease with damage of the heart valves.