ARTERIAL HYPERTENSION IN SYSTEMIC VASCULITIS

Bevzenko T.B.¹, Golovach I.Yu.², Iermolaieva M.V.³, Sedaia L.V.⁴, Syniachenko O.V.³

• ¹Научно-практический центр профилактической и клинической медицины, Киев
• ²Feofaniya Clinical Hospital, Kyiv
• ³Донецкий национальный медицинский университет, Лиман
• ⁴Донецкий национальный медицинский университет им. Максима Горького, Красный Лиман

Summary. The purpose and objectives of the study — to estimate the incidence of arterial hypertension (AG) in Henoch-Schonlein Purpura (HSP), idiopathic cryoglobulinemic vasculitis (ICV), Wegener’s granulomatosis with polyangiitis (WGPA), microscopic polyangiitis (MPA), polyarteritis nodosa (PAN), eosinophilic granulomatous polyangiitis Churg-Strauss (EPA) and Takayasu’s aortoarteritis (TAA), to study the risk factors of high blood pressure (BP) in systemic vasculitis (SV), and relations with other manifestations of the disease. Тhe study included 503 patients with SV, and the ratio of the number of patients with HSP, MPA, ICV, PAN, EPA, TAA, WGPA was as 7: 3: 3: 1: 1: 1: 1. Increased blood pressure is observed in 72% of patients with PAN, in 69% of TAA, in 65% ICV, in 61% MPA, in 54% WGPA, in 25% HSP, in 20% of the EPA, that correlates directly with the parameters of peripheral vascular resistance with high reliable, is associated with the patient’s age, duration of disease, the degree of activity of pathological process, and the development of hypertension affects integral severity of clinical signs of SV, multivariate analysis of variance and multiple regression analysis demonstrate that. Hypertension has partly symptomatic renal character, affects heart disorders (in HSP, ICV, MPA), joints (HSP, EPA) and kidney (HSP), determining the glomerular filtration rate and the rate of progression of nephropathy, and an increase in blood pressure correlates with the overall severity of vascular pathology and the nature of vasodilation.