The balance between benefits and risks in the therapy of rheumatoid arthritis

Rekalov D.H.¹, Kulynych A.V.², Kravchenko V.I.¹, Prytkova A.V.², Bryner I.A.², Daniuk I.A.²

• ¹Zaporizhzhya state medical university
• ²КП «Запорожская областная клиническая больница» Запорожского областного совета

Summary. One of the important strategies for effective and efficient treatment of rheumatoid arthritis (RA) is associated with the early use of synthetic disease-modifying antirheumatic drugs (sDMARD) and biological agents (BA), both as monotherapy and in combination. In this paper, we analyzed the data concerning systematic approach in the treatment of RA in a variety of clinical situations, as well as to determine the indications for the patients with a poor adherence on BA monotherapy and long-term treatment associated with inefficiency and/or toxicity of traditional sDMARDs.