THE INFLUENCE OF VITAMIN D LEVEL ON THE MARKERS OF DISEASE ACTIVITY IN PATIENTS WITH RHEUMATOID ARTHRITIS

Povorozniuk V.V. ¹, Synenkyi O.V. ², Balatska N.I.¹

• ¹ДУ «Інститут геронтології ім. Д.Ф. Чеботарьова НАМН України», Київ
• ²Львівський національний медичний університет ім. Данила Галицького

Summary. The aim of the study was to evaluate the influence of serum 25(OH)D level on the disease activity markers in patients with rheumatoid arthritis. The study involved 93 patients aged 27–80 years, 74.2 % were women. Mean age of women was (53.45±11.16) and men — (53.29 ±12.06) years old (р>0.05). Mean duration of the disease was (8.59±5.99) years. It was found that 54.84 % of the examined had vitamin D deficiency, and 37.63 % — insufficiency. Serum 25(OH)D level was markedly lower in patients with the highest activity of rheumatoid arthritis that in patients with the minimal activity (16.55±9.26 vs 22.59±9.74 ng/ml; p<0.05). In patients with rheumatoid arthritis serum 25(OH)D level was significantly and negatively associated with markers of disease activity (DAS28-ESR (β=–0.33; 95% CI 0.05, –0.01), CRP (β=–0.23; 95% CI –0.72; 0.00), and ESR (β=–0.26; 95% CI –0.78; –0.10)). All this associations remained statistically significant after adjustment for gender, age and BMI. Vitamin D deficiency can be regarded as a significant predictor of the highest activity of rheumatoid arthritis (AUROC=0.67; 95% CI 0.513–0.83; р=0.05).