PARAMETER IMMUNOPATHOLOGICAL REACTIONS IN PATIENTS WITH CHRONIC HEART FAILURE DEPEND ON INSULIN RESISTANCE
Voronkov L.G. , Gavrilenko T.I., Ilnytska M.R., Yakyshko L.V. , Ryzhkova N.O.
Summary. We examined 107 pts with chronic heart failure (CHF) II–IV NYHA class without diabetes with reduced ejection fraction left ventricular, and 15 healthy donors. All pts were divided into 2 groups depending on presence of insulin resistance (IR) (index HOMA ≥2.77). Levels of insulin, leptin, adiponectin in blood serum, levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-10 in blood serum and supernatants of blood mononuclears were determine by IFA-methods. We studded the levels of autoantibody and degree of sensibilization of lymphocytes to antigens pancreas tissues. It has been found active of immunoinflammatory reaction which was expressed intensification TNF-α, IL-6 in of blood mononuclear cells in pts with CHF, irrespective of the IR. In pts with CHF and IR reliable express of autoimmunization both on cells type and both of humorals type was established. It was directed reliable connection between the levels of TNF-α, IL-6 in blood serum and the degree of autosensibilization of lymphocytes, autoantibodies to antigens pancreas tissues in IR-pts with CHF. Also, in this pts we observed significantly higher levels of leptin and ratio leptin/adiponectin in comparison with control group.
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