FRACTURES RISK FACTORS ANALYSIS IN PATIENTS WITH MYOCARDIAL INFARCTION

Nishkumay O.I.¹, Povoroznyuk V.V.², Kordubailo I.A.², Lisak Z.V.¹

• ¹O.O. Bohomolets National Medical University, Kyiv
• ²Alexander Clinical Hospital, Kyiv

Summary. The results of the latest studies indicate common pathogenetic mechanisms that lead to the development of osteoporosis and atherosclerosis and point out a correlation between the decrease of bone mineral density and the aorta calcification degree. The aim of the study was to examine the presence of bone fractures risk factors in patients with myocardial infarction and coronary atherosclerosis. Materials and methods. 46 patients (16 females, mean age 58±14,1 years, menopause duration 10.6±7.7 years, and 30 men, mean age 55.7±9.2 years) were examined. Coronary arte­ries stenosis >75% was detected by coronary angiography in all patients with myocardial infarction. Fracture risk factors analysis showed an insufficient intake of calcium in the daily diet, a history of low energy fractures in 33% of patients, and for wo­men — low-energy fractures in parents. The probability of fracture with the FRAX calculator was higher in women without gender differences in the densitometry data. The correlation analysis revealed a positive correlation between low-energy fractures and TG levels (r=0.4; p<0.05). Results. Positive correlation is established between the densitometric measure of the SOS data (which shows the elasticity of a bone) and the level of VLDL (r=0,66; p<0.05). The received data may indicate that decrease of bone mineral density leads to the arterial wall elasticity reducing.