EXPERIENCE OF SUCCESSFUL TREATMENT OF PYODERMA GANDRENOSUM. CLINICAL CASE

Horbal N.M.¹, Ivanyk O.S.², Synenkyi O.V. ¹, Chopyak V.V.¹, Terletskyy I.R.¹, Verhola M.R.¹

• ¹Львівський національний медичний університет ім. Данила Галицького
• ²ДУ «Інститут геронтології ім. Д.Ф. Чеботарьова НАМН України», Київ

Summary. Pyoderma gangrenosum is a rare inflammatory neutrophilic dermatosis which can manifest like chronic focal gangrene of skin with unknown etiology, often associated with internal diseases. PG has been estimated to occur in three to ten individuals per million. The peak of incidence occurs between the ages of 20 to 50 years with women being more often affected than men. Diagnostics of this disease can be difficult even for experienced specialists, because it is a rare pathology in clinical practice. Besides, there are no patognomic biomarkers, clinical or histological features clearly defined diagnostic criteria. In many ca­ses pyoderma gangrenosum is associated with an underlying disease, most commonly inflammatory bowel disease, rheumatic or haematological disease and malignancy. In the article there are presented the results of our own clinical observation of pyoderma gangrenosum case and successful treatment of it (which included steroids, antibiotics, surgical wound care) and literature data about this problem. This clinical case is interesting because of low prevalence of dermatosis, severe course of disease and full scaring as a consequence of complex treatment. Late verification of diagnosis and delayed start of treatment, despite the aggressive course, is conditioned with rareness and the complexity disease.