POLYMORPHISM Q223R (RS1137101) OF THE LEPR GENE IN PATIENTS WITH KNEE OSTEOARTHRITIS
Novoseletskyi V.O., Stanislavchuk М.А. , Shkarupa V.M.
Summary. Osteoarthritis (OA) is the most common joint disease of unspecified etiology in which the genetic factor plays a crucial role. Single nucleotide polymorphisms (SNP) have been demonstrated to be associated with susceptibility to osteoarthritis. The contribution of allelic polymorphism Q223R (rs1137101) of the LEPR gene to knee osteoarthritis susceptibility in Ukrainian women has been previously unexplored. The present study is aimed at investigation whether Q223R (rs1137101) polymorphism is related with the risk of knee osteoarthritis in female population of Podillya region of Ukraine. Objects and methods. Q223R (rs1137101) polymorphisms were genotyped in 99 patients (female) with knee OA and in 62 age-matched female healthy controls using PCR-RT analysis. Results. There was established associative relation between those carrying the GG genotype and the OA of the knee joints in the recessive genetic model (GG versus AA+GA) (OR 2.15; p=0.04). Conclusions. Our findings suggest that the genetic variant of LEPR gene rs1137101 is related to knee osteoarthritis susceptibility in Ukrainian population and may serve as a potential biomarker to determine the risk of knee osteoarthritis.
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