CIRCADIAN PROFILE OF BLOOD GALECTIN-3, INTERLEUKIN-1β AND CARTILAGINOUS OLIGOMERIC MATRIX PROTEIN INDICES IN PATIENTS WITH KNEE JOINT OSTEOARTHROSIS
Humeniuk O.V. , Stanislavchuk M.A., Zaichko N.V.
Summary. We have examined the circadian profile of the galectin-3 blood serum level in patients with knee joint osteoarthrosis (OA) and evaluated its connection with circadian changes in the levels of interleukin (IL)-1β and cartilage oligomeric matrix protein (COMP) in the blood. It has been found that OA patients demonstrated a significant increase in the level of serum galectin-3 compared with practically healthy subjects. The level of galectin-3 does not present with a circadian nature, unlike the levels of IL-1β (nocturnal growth) and COMP (nocturnal drop). Higher levels (1.6–1.7-fold) of galectin-3 were reported in Stage III OA patients diagnosed synovitis. The increase in the level of galectin-3 correlated with age and duration of OA, and perhaps stronger associated with a growth of blood SOMR and IL-1β. The growth of serum galectin-3 is a marker of progression of inflammatory and destructive changes in the joints of OA patients.
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