Informative value of various methods for assessing the risk of cardiovascular disease in women with rheumatoid arthritis

Garmish O.O. ¹, Levchenko V.G.²

• ¹SI «NSC «Institute of Cardiology M.D. Strazhesko» NAMS of Ukraine», Kyiv
• ²Державна установа «Національний науковий центр «Інститут кардіології ім. М.Д. Стражеска» НАМН України», Київ

Summary. The purpose of the study is to investigate the informativeness of different scales-calculators for assessing the 10-year risk of cardiovascular diseases (CVD) in women with rheumatoid arthritis (RA). A total of 135 patients were examined according to protocol conditions. A 10-year CVD risk assessment was carried out on SCORE, mSCORE, Reynolds Risk Score, Framingham Risk Score, QRISK2, QRISK3. To evaluate the cIMT, duplex scanning was conducted according to the procedure recommended for use in clinical trials in B-mode with the determination of cIMT at three points. The criterion for estimating the cIMT was 0.9 mm. The informativeness of the scales-calculators was assessed by the sensitivity and specificity indicators in comparison with the cIMT. Statistical processing of data was performed using variational statistics methods using the program Statistica 7.0. In women with RA, the 10-year risk of CVD is significantly higher in comparison with the control group for all studied scales-calculators. The index of cIMT in patients with RA is significantly larger in comparison with the control group due to the shift of the dispersion of the indicator towards higher values. Informativeness of use of scales-calculators for assessment 10-year risk of CVD in patients with RA is characterized by low sensitivity and high specificity, which makes it impossible to use them as an independent methodology for assessing the risk of CVD in clinical practice.