CLINICAL-PATHOGENETIC IMPORTANCE OF MEDIUM-MOLECULAR COMPOUNDS UNDER THE GIFT
Syniachenko O.V., Iermolaieva M.V., Fedorov D.M., Pylypenko V.V.
Summary. Relevance. The main factor in the pathogenesis of gout is the disorder of purine metabolism, in particular, uric acid and its metabolites, nitrogenous bases and enzymes, which have relationships with many medium-molecular compounds of hormonal, peptide and lipid nature, the clinical and pathogenetic significance of which, in different variants of arthritis and nephropathy, has not been found out yet. The purpose of the study was to study the role of medium mass molecules (MMM) of different fractions, medium molecular hormones and peptides in articular and renal syndromes among patients with gout. Material and methods. 105 patients with primary gout were examined, 92% of men and 8% of women aged between 26 to 76 years (51 years on average), and women were 8 years older. The average duration of the disease was 12 years. The first sign of gout among 91% of the patients was the joint crisis, and in the remaining cases ‒ renal colic. The ratio of the frequency of intermittent and chronic forms of arthritis was 2:1, the latent type of nephropathy occurred in 66% of cases, urolithiasis in 34%, and the ratio of stages I, II, III and IV of chronic kidney disease was 4:2:1:1. The content of the MMM of the aminopeptide fraction, peptide, nucleotide, chromatophoric, averaged and integral medium-molecular index, insulin, calcitonin, osteocalcin, endothelin-1, atrial natriuretic peptide and cerebral was studied in the blood serum. Patients without exacerbation of arthritis were examined. Conclusions. MMM of different fractions, medium-molecular hormones and peptides participate in pathogenetic development of articular and renal syndromes in cases of gout and have a great prognostic significance.
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