CARDIOVASCULAR PATHOLOGY IN PATIENTS WITH ANKILOSING SPONDILITE: REVIEW OF LITERATURE AND OWN OBSERVATIONS
Yehudina Ye.D.1, Golovach I.Yu.2
Summary. Ankylosing spondylitis (AC) belongs to the spondyloarthritis group. The spine and sacroiliac joints with possible development of peripheral arthritis in the pathological process are mainly involved. Extra-articular lesions in AS are ophthalmologic, cardiovascular, pulmonary or neurological manifestations. The pathology of the cardiovascular system is observed in 2–10% of patients, having a significant impact on the mortality and course of the disease as a whole. In the present work, cardiac complications characteristic of AS have been analyzed, such as aortitis, periaortitis, aortic regurgitation, atrioventricular blockade, thickening of aortic and mitral valves, pericarditis and left ventricular dysfunction. The most common clinical manifestations of cardiovascular disease are conduction disorders and aortic insufficiency. The cardiovascular system involvement is most common in patients with a long history of AS, HLA-B27-associated course, peripheral joints affection. Subclinical changes in the cardiovascular system in AS should be differentiated and observed to determine their prognostic value and clinical course. Electrocardiography and evaluation of echocardiography should be part of the routine management of patients with AS.
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