KIDNEY DISORDER IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS: IMPORTANCE OF HISTOLOGICAL DIAGNOSIS IN THE RATIONAL THERAPY CHOICE. CLINICAL CASE

Tripolka S.A.¹, Golovach I.Yu.², Dyadyk O.O.³

• ¹Communal non-profit enterprise of the Kharkiv Regional Council «Regional Clinical Hospital», Kharkiv
• ²Feofaniya Clinical Hospital, Kyiv
• ³Национальная медицинская академия последипломного образования им. П.Л. Шупика, Киев

Summary. The article presents modern approaches to the diagnosis of lupus nephritis. Pathological changes in lupus glomerulonephritis are described, and characteristics of the lupus nephritis classes are given. To date, none of the serum or urinary biomarkers of the disease activity exceeds the information content obtained by histopathological examination of kidney biopsies. Thus, the classification of lupus glomerulonephritis is determined by the results of pathological studies. The article is illustrated with photographs of histopathological changes of the kidneys in various classes of nephritis. A clinical case of monitoring a patient with systemic lupus erythematosus and kidney damage is presented. Nephrobiopsy followed by histopathological examination allowed us to establish the class of nephritis, as well as to change the ongoing immunosuppressive therapy. This clinical case emphasizes the need and feasibility of a biopsy of the kidneys and the establishment of the morphological class of nephritis as early as possible in the disease, which will allow more targeted selection of therapy and success in treatment at earlier stages.