Pleiotropic effects of some anti-inflammatory drugs used in the treatment of osteoarthritis

Shuba N.M. , Voronova T.D., Krylova A.S., Humber T.S., Pilipenko A.V.

• National Medical Academy of Postgraduate Education named after P.L. Shupik, Kyiv

Summary. A differentiated approach to the treatment of patients with osteoarthritis (OA) has always been a complex problem. In respect that patients with OA usually are over the age of 40 years, and therefore have not a single comorbid disease, which greatly complicates the choice of effective treatment. The article presents the effectiveness of the most commonly used drugs used in the treatment of patients with OA: nonsteroidal anti-inflammatory drugs (diclofenac, nimesulide, meloxicam) and symptomatic slow-acting anti-inflammatory drugs (chondroitin sulfate, glucosamine sulfate, diacerein, ginger root extract, avo­cado soybean unsaponifiables), as well as their influence on the indices of purine, carbohydrate, lipid metabolism and the possibility of their safe use in person with concomitant pathology.