EVIDENCE ON THE SAFETY OF NIMESULIDE, A VIABLE ALTERNATIVE TO COXIBS
Summary. Nimesulide, due to its rapid anti-inflammatory and analgesic effects, was and remains one of the most popular non-steroidal anti-inflammatory drugs (NSAIDs). Thus, in Ukraine, in terms of the number of outpatient appointments, it ranks 4-rd in its group (Rx test, 2022). At the same time, the understanding of various aspects of the pharmacological action of this NSAID continues to develop, as and new molecular mechanisms underlying based on its anti-inflammatory action and favorable safety profile for the gastrointestinal tract and cardiovascular systems. Taking into account the significantly expanded pharmacotherapeutic concepts, it is possible to better outline the scope of nimesulide’s application and even outline new promising therapeutic directions for it.
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