EFFECTIVENESS OF UNDENATURED COLLAGEN TYPE II IN KNEE OSTEOARTHRITIS TREATMENT IN COMPARE TO GLUCOSAMINE AND CHONDROITIN COMBINATION

Rekalov D.G.¹, Golovach I.Yu.², Dotsenko S.Ya.³, Danyuk I.O.³, Kulynych R.L.³, Shevchenko M.V.³, Krupko V.V.¹

• ¹«Professor Rekalov Rheumatology Clinic», Dnipro
• ²Feofaniya Clinical Hospital, Kyiv
• ³Zaporizhzhia State Medical University, Zaporizhzhia, Ukraine

Summary. Objective. The autoimmune degradation of type II collagen plays the important role in the pathogenesis of osteoarthritis (OA) and searching for a chondroprotective agent that would reduce the autoimmune mechanisms of collagen degradation is actual. The perspective agent is undenatured collagen type II (UC-II), administration of which contributes to the formation of immune tolerance. Purpose. To determine the beginning of clinical effectiveness and its dynamics during 180-day period of treatment of UC-II in compare to glucosamine and chondroitin (G+Ch) combination in patients with Grade II knee OA. Materials and methods: 40 patients with Grade II knee OA were investigated. Main group (20 patients) were administrated the UC-II, comparison group (20 patients) took the combination of G+Ch during 180-day period. WOMAC scale was used to evaluate the effectiveness. Results. The therapy with UC-II demonstrated the significant benefit in reducing pain syndrome, joint stiffness and improving the most indicators of joint function in compare to G+Ch combination in the end of study. The analysis of WOMAC subscales during 180-day period demonstrated the earlier beginning of clinical improvement in UC-II group (after 1 month of treatment), while in G+Ch group – in the end of the 2nd month. The dynamics of efficiency in the UC-II group in compare to G+Ch group characterized by gradual course and stable improvement of the most WOMAC subscales. Conclusions. The administration of UC-II in Grade II knee OA treatment has benefit in compare to G+Ch combination and demonstrates the significantly better effect in pain relief, reduction of stiffness and improvement of the main joint functions.