The state of the psycho-emotional sphere in patients with systemic lupus erythematosus, the relationship with the course of the disease
Stepaniuk T.V.1, Shevchuk S.V.1,2
- 1Vinnytsia National Medical University named М.І. Pirogov
- 2Research Institute of Rehabilitation of Persons with Disabilities of Vinnytsia National Medical University named М.І. Pirogov
Summary. Damage to the nervous system in case of systemic lupus erythematosus (SLE) is a significant problem and has a variety of clinical manifestations. Damage to the psycho-emotional sphere, which manifests itself by anxiety and depressive disorders, as well as cognitive dysfunction, acquire special importance. However, the causes and mechanisms of development of these violations are still far from being fully understood. Purpose: to study the prevalence of psycho-emotional disorders (depression, anxiety, cognitive dysfunction) in patients with systemic lupus erythematosus and to assess their relationship with the course of the disease. Materials and outcomes. 96 patients with SLE were examined, the average age of which was 37.5±0.9 years, the duration of the disease was 6.2±0.4 years. All patients were examined by a neurologist and a psychiatrist, in addition, the following were used to assess the psychoneurological state: Zung’s depression self-assessment scale, Spielberger’s anxiety scale, Montreal scale of cognitive function assessment (MoCA), visual and auditory memory tests. Outcomes. Patients with SLE often have disorders in the psycho-emotional sphere. Depressive and anxious manifestations, as well as cognitive dysfunction of varying degrees of expressiveness, are found in 81.2%, 32.3%, and 42.7% of the patients, respectively. Most often, they are represented by a high and medium level of anxiety, mild and moderate depressive changes, mild cognitive disorders. Lesions of the nervous system are associated with high activity of the inflammatory process according to SLEDAI and SLICC/DI damage index. Conclusions: Disorders in the psycho-emotional sphere lack significant associative relationships with age, sex, and duration of the disease, and are associated with the total SLEDAI activity index and the SLICC/DI impairment index.
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