Features anemic syndrome in patients with systemic lupus erythematosus

Shevchuk S.V.¹, Kurylenko I.V.²

• ¹National Pirogov Memorial Medical University, Vinnytsya
• ²Український державний науково-дослідний інститут реабілітації інвалідів МOЗ України

Summary. This paper investigates the relationship between different forms of anemia syndrome in SLE patients with clinical and laboratory parameters of disease activity and severity. 233 patients with SLE were examined, and anemia was diagnosed in 127 of them. The blood content of proinflammatory cytokines, nitric oxide metabolites and routine markers of the SLE activity were investigated. The most common forms of anemia in SLE are anemia of chronic disease (AHD), iron deficiency anemia (IDA) and AHD with iron deficiency. AHD were characterised by normotsytoz, low iron-binding plasma capacity, moderately low iron, high ferritin content, moderately elevated levels of transferrin receptors and low ratio rTF/logFer. When IDA on the background of iron deficiency occur mikroсytoz, high levels iron-binding plasma capacity, the ratio rTF/logFer and moderate increase in ferritin. SLE patients with signs of AHD have higher levels of markers of inflammation than patients with IDA, which indicates the important role of inflammatory process in the formation of AHD in SLE.