The features of lipid spectrum of patients with antiphospholipid syndrome

Shevchuk S.V.¹, Segeda U.S. ², Kuvikova I.P. ³

• ¹National Pirogov Memorial Medical University, Vinnytsya
• ²Науково-дослідний інститут реабілітації інвалідів (навчально-науково-лікувальний комплекс) Вінницького національного медичного університету ім. М.І. Пирогова
• ³Науково-дослідний інститут реабілітації інвалідів Вінницького національного медичного університету ім. М.І. Пирогова, Вінниця

Summary. Summary. The aim of the study was to observe the features of lipid spectrum of patients with antiphospholipid syndrome and its association with the course of disease. The study included 138 patients, among whom 34 (24.6%) patients with primary APS, 43 (31.2%) — with secondary APS and 61 (44.2%) — with SLE without APS, comparable in age and duration of disease. Dyslipidemia was found in 65.4% of patients with secondary APS and 38.2% of primary APS The most common disorders of lipid metabolism among patients with secondary APS was hypertriglyceridemia (51.1%) and an increase of LDL level (41.9%), in patients with primary APS — hipoalfacholesterynemiya (35.3%). Lipid metabolism in patients with SAPS closely correlated with the activity index SLEDAI and TNF-alpha level and weakly depends on the sex of the patient, age and disease duration. It was revealed close relationship of dyslipidemia with age and duration of disease, weak association with activity of the inflammatory process and the lack of relationship with the sex of patients.