The capabilitsts of systemic enzyme therapy in prevention and progression of peripherical arteries structural and functional disorders in patients with metabolic syndrome and osteoarthritis

Mitchenko O.I. ¹, Sirenko Yu.M.², Kozliuk А.³

• ¹Державна установа «ННЦ «Інститут кардіології ім. М.Д. Стражеска» НАМН України»
• ²ДУ «Національний науковий центр «Інститут кардіології ім. М.Д. Стражеска» НАМН України», Київ
• ³State Institution National Scientific Center «Institute of Cardiology named after acad. M.D. Strazheska» National Academy of Medical Sciences of Ukraine

Summary. Summary. The data of systemic enzyme therapy (SET) efficiency in prevention and progression of peripheral arteries structural and functional disorders in patients with metabolic syndrome and osteoarthritis are presented in article. We detected an evidence of arterial vascular remodeling and endothelial dysfunction in all patients with metabolic syndrome and osteoarthritis. Treatment with SET during 6 month period resulted in restoration of endothelial function оn macrovascular and microvascular levels, what was appeared in normalizing of flow mediated vasodilation. Treatment with SET was not associated with repairing structural disorders of arterial wall, but it was effective in prevention of progression violation of arterial vessel, which tendency was found in group without treatment.