Hyperhomocesteinemia in patients with antiphospholipid syndrome, its associations with disease course and cardiovascular system condition

Shevchuk S.V.¹, Kuvikova I.P. ²

• ¹National Pirogov Memorial Medical University, Vinnytsya
• ²Науково-дослідний інститут реабілітації інвалідів Вінницького національного медичного університету ім. М.І. Пирогова, Вінниця

Summary. Summary. In the article we analyzed the frequency hyperhomocesteinemia in patients with different types of APS. It was revealed the significant homocestein prevalence among patients with antiphospholipid syndrome and its close relationship with markers of endothelial dysfunction (endothelin-1, thrombomodulin) and structural and functional state of the heart and vessels. We explored that the level of homocestein in the serum of patients with antiphospholipid syndrome was associated with a genetic defect such as the replacement of cytosine to thymine at nucleotide 677 (677C → T), deficiency of vitamins B9 and B12, markers of inflammatory activity (CRP, IL-6). Also the level of homocestein was associated with high titers of anticardiolipin antibodies and antibeta-2 glycoprotein-1 antibodies, arterial hypertension, smoking, male gender and did not depend on the lipid metabolism, obesity, age and disease duration.