Structural and functional characteristic of bone tissue in patients with systemic lupus erythematosus

Shevchuk S.V.¹, Denyshchych L.P.²

• ¹National Pirogov Memorial Medical University, Vinnytsya
• ²Науково-дослідний інститут реабілітації інвалідів Вінницького національного медичного університету ім. М.І. Пирогова МОЗ України

Summary. Summary. This paper examines the prevalence of systemic osteopenic syndrome and osteoporosis in patients with systemic lupus erythematosus (SLE), their relationship with traditional risk factors, the course of disease and its activity. It is established that bone mineral density (BMD) at the lumbar spine in SLE patients is significantly lower than in healthy individuals. Osteopenia and osteoporosis are registered in 13.8 and 6.9% of healthy individuals, among SLE patients — in 31.7 and 9.7% of cases, herewith, the vertebral fractures of the last group of individuals occur in 19.5%. It is proved that decrease of bone mineral density in patients with SLE is associated not only with reproductive women’s aging, but also with the duration of disease, severity of organ damage, inflammatory activity and total dose of glucocorticoids, but no correlation was found with smoking or obesity.