THE LEVEL OF C-TERMINAL TELOPEPTIDE OF TYPE I COLLAGEN IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS: THE RELATIONSHIP WITH COURSE OF THE DISEASE AND STRUCTURAL AND FUNCTIONAL STATE OF BONE TISSUE

Shevchuk S.V.¹, Denyshchych L.P.², Marynych L.I.¹

• ¹National Pirogov Memorial Medical University, Vinnytsya
• ²Науково-дослідний інститут реабілітації інвалідів Вінницького національного медичного університету ім. М.І. Пирогова МОЗ України

Summary. Summary. The study evaluated level of serum carboxiterminal telopeptide of type I collagen (CTX) in patients with systemic lupus erythematosus (SLE), its relationship with structural and funсtional state of bone tissue, fractures and course of the disease. The study involved 58 SLE female patients. The mean age was 45,44±1,03 years. The control group included 29 healthy age- and sex-matched individuals. Our findings suggest, that 25.9% of SLE patients and 6.9% of the control group have increased content of CTX and it closely associated with the severity and the activity of the disease, high levels of C reactive protein (CRP) and interleukin-6 (IL-6), age, cumulative glucocorticoid dose and substantially independent of disease duration, BMI and smoking. The patients with osteopenia, osteoporosis and fractures were significantly more frequently found among patients with increased bone resorbtion rate.